Background
Antibiotic Resistance
Bacteria are rapidly becoming resistant
towards
antibiotics, representing one
of the greatest
threats
to
human health
worldwide.
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Infections in Surgical Wounds
Surgical Site Infections, SSIs, causes patient
suffering
and significant hospital costs. SSIs
are
today treated with
antibiotics.
As antibiotic resistance against antibiotics
continue
to
develop, the requirements of an
non-antibiotic
therapy
to treat surgical
infections increases.
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One alternative to antibiotics is
use
of
non-
selective, bacteria
killing
agents.
By encap-
sulating these substances
in
Seek & Heal™
particles, they
will selectively
kill
bacteria.
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Nanoparticles
The size of the particles
should
be less
than
that of
the
bacteria
they
adhere to.
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Four batches of nanoparticles
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Prophylactic Disinfection
Therapy for Surgical Wounds
To decrease patient suffering and save hospi-
tal
costs,
Microbionical has developed a product
for
prophylactic
disinfection of
surgical wounds.
Before the wound is closed, it is washed with
a solution containing encapsulated antiseptic.
Antiseptics
Use of antiseptic
substances is
avoided in
modern
wound care because they
cause
pro-
longed
wound
healing
and
scar
formation.
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Seek & Heal™ - Drug Targeting
The product consists of particles that selective-
ly adhere to bacteria in wounds. The particles
do not adhere to human tissues.
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After adhering to the bacteria,
the
particles
release an antimicrobic substance. Various
types of substances may be
incorporated
into the particles.
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Treating resistant bacteria
Use of encapsulated antiseptic
agents
in
wounds
gives
the
opportunity
to
treat
infections caused by both
normal
and resistant
bacteria.
Verifications
In the
laboratory, Seek & Heal™ particles
are
not
interacting
with
blood
components.
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Seek & Heal™ particles
are strongly adhe-
ring
to
bacteria.
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An antiseptic substance encapsulated in
Seek & Heal™ particles kills bacteria as
efficient as not encapsulated drug.
...read more
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