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Antibiotic resistance
Surgical wound infections
Nanotechnology
Antimicrobial peptides
 
Seek & Heal™ targeting
Targeting verification
Antimicrobial substance
Bactericide verification
Tissue friendly verification
 
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 Seek & Heal™ Therapy for Antibiotic Resistance 

 

Background

Antibiotic Resistance

Bacteria are rapidly becoming resistant towards
antibiotics, representing one of the greatest
threats to human health worldwide.

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Infections in Surgical Wounds

Surgical Site Infections, SSIs, causes patient
suffering and significant hospital costs. SSIs
are today treated with antibiotics.

As antibiotic resistance against antibiotics continue
to develop, the requirements of an non-antibiotic
therapy to treat surgical infections increases.

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One alternative to antibiotics is use of non-
selective, bacteria killing agents. By encap-
sulating these substances in Seek & Heal™
particles, they will selectively kill bacteria.

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Nanoparticles

The size of the particles should be less than that of
the bacteria they adhere to.

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Four batches of nanoparticles

 

 

Prophylactic Disinfection

Therapy for Surgical Wounds

To decrease patient suffering and save hospi-
tal costs, Microbionical has developed a product
for prophylactic disinfection of surgical wounds.

Before the wound is closed, it is washed with
a solution containing encapsulated antiseptic.

Antiseptics

Use of antiseptic substances is avoided in
modern wound care because they cause pro-
longed wound healing and scar formation.

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Seek & Heal™ - Drug Targeting

The product consists of particles that selective-
ly adhere to bacteria in wounds. The particles
do not adhere to human tissues.

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After adhering to the bacteria, the particles
release an antimicrobic substance. Various
types of substances may be incorporated
into the particles.

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Treating resistant bacteria

Use of encapsulated antiseptic agents in
wounds gives the opportunity to treat infections caused by both normal and resistant bacteria.

Verifications

In the laboratory, Seek & Heal™ particles
are not interacting with blood components.

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Seek & Heal™ particles are strongly adhe-
ring to bacteria.

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An antiseptic substance encapsulated in
Seek & Heal™ particles kills bacteria as
efficient as not encapsulated drug.

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